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From the East:

Take the Mass Pike West to Exit 13 (Framingham Route 30).
Take Route 30 West to Route 9 West.
Turn right at the first traffic light onto Prospect Street.
At the end of Prospect Street, turn left onto Central Street.
St. Patrick's Manor is on the right.

From the West:

Take the Mass Pike East to Exit 12 (Framingham Route 9).
Take Route 9 East through three traffic lights.
Turn left at the fourth traffic light onto Prospect Street.
At the end of Prospect Street, turn left onto Central Street.
St. Patrick's Manor is on the right.